Cation antagonism in blood coagulation

Changes in blood coagulation.

Studies in Blood Coagulation

Description is given of changes in blood coagulability found in diseases of the rabbit, including malignant tumor, spontaneous infections, non-bacterial diseases and lesions, and hemorrhagic states specifically induced. The changes involved variously the time of onset of blood coagulation, clot formation rate and the rate and extent of clot retraction.

Coagulation in Embryonic Blood

1. In pig embryos of 100 to 270 mm. the average coagulation time of the blood was found to be about 23 minutes. This represents a coagulation time six to eight times greater than that obtained for the adult. 2. The first evidence of coagulation in the blood of these embryos consisted in the appearance of small masses of fibrin deposited almost invariably at the side of the test-tube. The ensuin...

Studies in Blood Coagulation

Crude or crystalline trypsin in proper concentration causes the blood or plasma of human beings, dogs, rabbits, guinea pigs, and horses to coagulate. It does not clot the fibrinogen directly, but reacts with prothrombin to form thrombin. Since trypsin thus has the same effect as the physiological system Ca plus platelets (or Ca plus tissue extracts), it is suggested as a tentative working hypot...

TMEM16F Forms a Ca2+-Activated Cation Channel Required for Lipid Scrambling in Platelets during Blood Coagulation

Collapse of membrane lipid asymmetry is a hallmark of blood coagulation. TMEM16F of the TMEM16 family that includes TMEM16A/B Ca(2+)-activated Cl(-) channels (CaCCs) is linked to Scott syndrome with deficient Ca(2+)-dependent lipid scrambling. We generated TMEM16F knockout mice that exhibit bleeding defects and protection in an arterial thrombosis model associated with platelet deficiency in Ca...